Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients

M Signorelli, M Ebrahimpoor, O Veth… - EMBO Molecular …, 2021 - embopress.org
DMD is a rare disorder characterized by progressive muscle degeneration and premature
death. Therapy development is delayed by difficulties to monitor efficacy non‐invasively in …

TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy

D Xu, S Li, L Wang, J Jiang, L Zhao… - Journal of cachexia …, 2021 - Wiley Online Library
Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in
regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 …

[HTML][HTML] Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice

X Bai, X Zhang, R Fang, J Wang, Y Ma, Z Liu… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
Studies reveal a linkage of miR-29s in aging and Parkinson's disease (PD). Here we show
that the serum levels of miR-29s in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

Plasma lipidomic analysis shows a disease progression signature in mdx mice

R Tsonaka, A Seyer, A Aartsma-Rus, P Spitali - Scientific Reports, 2021 - nature.com
Duchenne muscular dystrophy (DMD) is a rare genetic disorder affecting paediatric patients.
The disease course is characterized by loss of muscle mass, which is rapidly substituted by …

Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice

C Xin, X Chu, W Wei, B Kuang, Y Wang… - Human Molecular …, 2021 - academic.oup.com
Duchenne muscular dystrophy (DMD) is a severe X-linked inherited muscular disorder
characterized by the loss of dystrophin. We have previously shown that monogene therapy …

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

N Ran, C Lin, L Leng, G Han, M Geng, Y Wu… - EMBO Molecular …, 2021 - embopress.org
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in
Duchenne muscular dystrophy (DMD), a devastating muscular disease caused by frame …

[PDF][PDF] Implication de la voie RANK/RANKL/OPG dans la physiopathologie musculaire et potentiel thérapeutique de l'anti-RANKL pour la dystrophie musculaire de …

D Hamoudi - 2021 - core.ac.uk
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder caused by
mutations in the gene encoding dystrophin located on chromosome Xp21. The absence of …

[PDF][PDF] Se er,., artsma-Rus,., & Spitali, P.(2021)

R Tsonaka - Plasma lipidomic anal sis shows a disease … - scholarlypublications …
Materials and methods Mice. All mice involved in the experiments were males and they were
housed in individually ventilated cages. Five groups of mice were included in the …

Exploring fibrosis in muscular dystrophy through modulation of the TGF-beta pathway

MWS Andre - 2021 - search.proquest.com
The extracellular matrix (ECM) of the skeletal muscle provides the framework for the muscle
structure and plays a key role in the repair and maintenance of myofibers through the …