Central nervous system diseases related to pathological microglial phagocytosis

K Wang, J Li, Y Zhang, Y Huang… - CNS Neuroscience …, 2021 - Wiley Online Library
Microglia are important phagocytes of the central nervous system (CNS). They play an
important role in protecting the CNS by clearing necrotic tissue and apoptotic cells in many …

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

J Lv, M Di Biase, RFH Cash, L Cocchi, VL Cropley… - Molecular …, 2021 - nature.com
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive
anatomical maps of structural brain changes associated with the disorder. We aimed to map …

A critical review of connectome validation studies

T Sarwar, K Ramamohanarao… - NMR in Biomedicine, 2021 - Wiley Online Library
Diffusion MRI tractography is the most widely used macroscale method for mapping
connectomes in vivo. However, tractography is prone to various errors and biases, and thus …

Isotopy and energy of physical networks

Y Liu, N Dehmamy, AL Barabási - Nature Physics, 2021 - nature.com
While the structural characteristics of a network are uniquely determined by its adjacency
matrix,–, in physical networks, such as the brain or the vascular system, the network's three …

Altered volume and structural connectivity of the hippocampus in Alzheimer's Disease and amnestic mild cognitive impairment

F Feng, W Huang, Q Meng, W Hao, H Yao… - Frontiers in aging …, 2021 - frontiersin.org
Background: Hippocampal atrophy is a characteristic of Alzheimer's disease (AD). However,
alterations in structural connectivity (number of connecting fibers) between the hippocampus …

Divergent alterations of structural–functional connectivity couplings in first-episode and chronic schizophrenia patients

L Kong, Y Huang, B Lei, P Ke, H Li, J Zhou, D Xiong… - Neuroscience, 2021 - Elsevier
Emerging evidence suggests that the coupling relating the structural connectivity (SC) of the
brain to its functional connectivity (FC) exhibits remarkable changes during development …

Combined support vector machine classifier and brain structural network features for the individual classification of amnestic mild cognitive impairment and subjective …

W Huang, X Li, X Li, G Kang, Y Han… - Frontiers in aging …, 2021 - frontiersin.org
Objective Individuals with subjective cognitive decline (SCD) or amnestic mild cognitive
impairment (aMCI) represent important targets for the early detection and intervention of …

[HTML][HTML] Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance

BAK Kreilkamp, A McKavanagh, B Alonazi, L Bryant… - NeuroImage: Clinical, 2021 - Elsevier
Despite an expanding literature on brain alterations in patients with longstanding epilepsy,
few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE) …

[HTML][HTML] Physical and digital phantoms for validating tractography and assessing artifacts

I Drobnjak, P Neher, C Poupon, T Sarwar - Neuroimage, 2021 - Elsevier
Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using
diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific …

Poly I: C‐induced maternal immune challenge reduces perineuronal net area and raises spontaneous network activity of hippocampal neurons in vitro

D Wegrzyn, MP Manitz, M Kostka… - European Journal of …, 2021 - Wiley Online Library
Activation of the maternal immune system (MIA) during gestation is linked to
neuropsychiatric diseases like schizophrenia. While many studies address behavioural …