While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Major depressive disorder (MDD) has been shown to be associated with structural
abnormalities in a variety of spatially diverse brain regions. However, the correlation …

Despite extensive study of the neurobiological correlates of post-traumatic stress disorder
(PTSD), little is known about its molecular determinants. Here, differential gene expression …

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …