Neurodegenerative disease: roles for sex, hormones, and oxidative stress

N Sumien, JT Cunningham, DL Davis… - …, 2021 - academic.oup.com
Neurodegenerative diseases cause severe impairments in cognitive and motor function.
With an increasing aging population and the onset of these diseases between 50 and 70 …

Hormonal and metabolic changes of aging and the influence of lifestyle modifications

MW Pataky, WF Young, KS Nair - Mayo Clinic Proceedings, 2021 - Elsevier
Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …

Testosterone and bone health in men: a narrative review

K Shigehara, K Izumi, Y Kadono… - Journal of Clinical …, 2021 - mdpi.com
Bone fracture due to osteoporosis is an important issue in decreasing the quality of life for
elderly men in the current aging society. Thus, osteoporosis and bone fracture prevention is …

Endocrinology of the aging prostate: current concepts

R Cannarella, RA Condorelli, F Barbagallo… - Frontiers in …, 2021 - frontiersin.org
Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

The critical role of oxidative stress in sarcopenic obesity

A Gonzalez, F Simon, O Achiardi… - Oxidative Medicine …, 2021 - Wiley Online Library
Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops
in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength …

The link between sex hormones and susceptibility to cardiac arrhythmias: from molecular basis to clinical implications

S Costa, AM Saguner, A Gasperetti, D Akdis… - Frontiers in …, 2021 - frontiersin.org
It is well-known that gender is an independent risk factor for some types of cardiac
arrhythmias. For example, males have a greater prevalence of atrial fibrillation and the …

[HTML][HTML] NK cells associate with ALS in a sex-and age-dependent manner

BJ Murdock, JP Famie, CE Piecuch, KD Pawlowski… - JCI insight, 2021 - ncbi.nlm.nih.gov
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …

Effects of calorie restricted low carbohydrate high fat ketogenic vs. non-ketogenic diet on strength, body-composition, hormonal and lipid profile in trained middle-aged …

V Vidić, V Ilić, L Toskić, N Janković, D Ugarković - Clinical Nutrition, 2021 - Elsevier
Background & aims The aim of this paper was to investigate and compare the effects of two
iso-energetic hypo-caloric ketogenic hyper-ketonemic and non-ketogenic low carbohydrate …

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: A pilot study

G Monastra, M Vazquez-Levin… - Basic and Clinical …, 2021 - Springer
Background Androgen deficiency affects men in the adulthood, causing several harmful
effects at the reproductive and behavioural levels. Since aromatase is an enzyme that …

Serum testosterone is inversely and sex hormone-binding globulin is directly associated with all-cause mortality in men

BB Yeap, RJ Marriott, L Antonio… - The Journal of …, 2021 - academic.oup.com
Context Serum testosterone concentrations decline with age, while serum sex hormone-
binding globulin (SHBG) concentrations increase. Objective To analyze associations of …