[HTML][HTML] The trinity of cGAS, TLR9, and ALRs guardians of the cellular galaxy against host-derived self-DNA
V Kumar - Frontiers in Immunology, 2021 - frontiersin.org
The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …
surrounding their environment. The immune system develops in such a way to recognize …
Molecular mechanisms of nonself nucleic acid recognition by the innate immune system
CC de Oliveira Mann, V Hornung - European journal of …, 2021 - Wiley Online Library
Nucleic acids (NAs) represent one of the most important classes of molecules recognized by
the innate immune system. However, NAs are not limited to pathogens, but are also present …
the innate immune system. However, NAs are not limited to pathogens, but are also present …
Human marginal zone B cell development from early T2 progenitors
B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through
T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B …
T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B …
[HTML][HTML] The role of nucleases and nucleic acid editing enzymes in the regulation of self-nucleic acid sensing
P Santa, A Garreau, L Serpas, A Ferriere… - Frontiers in …, 2021 - frontiersin.org
Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …
[HTML][HTML] Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
AL Gavin, D Huang, TR Blane, TC Thinnes… - Nature …, 2021 - nature.com
Abstract Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with
several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA …
several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA …
Enhanced proliferation of Ly6C+ monocytes/macrophages contributes to chronic inflammation in skin wounds of diabetic mice
Diabetic wounds are characterized by persistent accumulation of proinflammatory
monocytes (Mo)/macrophages (MΦ) and impaired healing. However, the mechanisms …
monocytes (Mo)/macrophages (MΦ) and impaired healing. However, the mechanisms …
The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy
ZP Van Acker, A Perdok, M Bretou, W Annaert - Ageing Research Reviews, 2021 - Elsevier
Microglia, the brain-resident immune cells, play an essential role in the upkeep of brain
homeostasis. They actively adapt into specific activation states based on cues from the …
homeostasis. They actively adapt into specific activation states based on cues from the …
[HTML][HTML] PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other
members of the phospholipase D superfamily. A coding variant in this gene confers …
members of the phospholipase D superfamily. A coding variant in this gene confers …
[HTML][HTML] Identification of a risk prediction model for clinical prognosis in HER2 positive breast cancer patients
D Zhou, Y Wu, K Jiang, F Xu, R Hong, S Wang - Genomics, 2021 - Elsevier
Background New biomarkers are needed to identify different clinical outcomes for HER2+
breast cancer (BC). Methods Differential genes of HER2+ BC were screened based on …
breast cancer (BC). Methods Differential genes of HER2+ BC were screened based on …
[HTML][HTML] N 6-Methyladenosine Methylomic Landscape of Lung Tissues in Murine Acute Allergic Asthma
F Teng, W Tang, T Wuniqiemu, J Qin, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Allergic asthma is well known as a common respiratory disorder comprising an allergic
inflammatory nature and excessive immune characteristic. N 6-methyladenosine (m6A) …
inflammatory nature and excessive immune characteristic. N 6-methyladenosine (m6A) …