The rapid evolution of resistance, particularly among Gram-negative bacteria, requires
appropriate identification of patients at risk followed by administration of appropriate empiric …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Surviving Sepsis Campaign: International... : Critical Care Medicine Executive Summary:
Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic …

OBJECTIVES: Existing studies evaluating the accuracy of heparin-binding protein for the
diagnosis of sepsis have been inconsistent. We conducted a systematic review and meta …

Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA
has emerged as a promising diagnostic technology for bloodstream infections. However, a …

Summary Sepsisshouldbedefinedaslife-threateningorgandysfunctioncausedbyadys…. Antibioticsarethecornerstoneofthetreatment…
. TheSurviving SepsisCampaign (SSC) recommendsthatcliniciansshouldperformem …

Although fever is one of the main presenting symptoms of COVID-19 infection, little public
attention has been given to fever as an evolved defense. Fever, the regulated increase in …

Lactate is the main product generated at the end of anaerobic glycolysis or during the
Warburg effect and its role as an active signalling molecule is increasingly recognised …

Urosepsis is a very serious condition with a high mortality rate. The immune response is in
the center of pathophysiology. The therapeutic management of these patients includes …

Background Septic shock is characterized by an uncontrolled inflammatory response and
microcirculatory dysfunction. There is currently no specific agent for treating septic shock …