Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) genome are expected to be either deleterious and swiftly purged or relatively …
JS Turner, JA O'Halloran, E Kalaidina, W Kim… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID- 19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …
C Motozono, M Toyoda, J Zahradnik, A Saito… - Cell host & …, 2021 - cell.com
Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the …
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus,. Here we describe a newly …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We …