Endothelial cells from umbilical cord of women affected by gestational diabetes: A suitable in vitro model to study mechanisms of early vascular senescence in …

P Di Tomo, N Alessio, S Falone… - The FASEB …, 2021 - Wiley Online Library
Human umbilical cord endothelial cells (HUVECs) obtained from women affected by
gestational diabetes (GD‐HUVECs) display durable pro‐atherogenic modifications and …

Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?

FA Francisco, LPJ Saavedra, MDF Junior… - Nutrition …, 2021 - academic.oup.com
Perinatal early nutritional disorders are critical for the developmental origins of health and
disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the …

[HTML][HTML] Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

X Zhang, A Rodriguez-Niño, DO Pastene, P Pallavi… - Scientific Reports, 2021 - nature.com
Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded
as a pivotal mediator of vascular damage in patients with diabetes. We have previously …

Effects of exposure to methylglyoxal on sperm motility and embryonic development after fertilization in mice

T Nakano, M Kono, K Segawa, S Kurosaka… - … of Reproduction and …, 2021 - jstage.jst.go.jp
Methylglyoxal (MG) is a precursor for the generation of endogenous advanced glycation end-
products involved in various diseases, including infertility. The present study evaluated the …