High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Single‐cell RNA sequencing in Drosophila: Technologies and applications

H Li - Wiley Interdisciplinary Reviews: Developmental …, 2021 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) has emerged as a powerful tool for investigating
cell states and functions at the single‐cell level. It has greatly revolutionized transcriptomic …

[HTML][HTML] Construction of heparin-based hydrogel incorporated with Cu5. 4O ultrasmall nanozymes for wound healing and inflammation inhibition

Y Peng, D He, X Ge, Y Lu, Y Chai, Y Zhang, Z Mao… - Bioactive Materials, 2021 - Elsevier
Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can
cause a feedback cycle of inflammation response that has a negative effect on cutaneous …

Metabolic remodelling during early mouse embryo development

J Zhao, K Yao, H Yu, L Zhang, Y Xu, L Chen, Z Sun… - Nature …, 2021 - nature.com
During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …

Reprogrammed blastoids contain amnion-like cells but not trophectoderm

C Zhao, AP Reyes, JP Schell, J Weltner, N M. Ortega… - biorxiv, 2021 - biorxiv.org
With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development

AJ Modzelewski, W Shao, J Chen, A Lee, X Qi, M Noon… - Cell, 2021 - cell.com
Retrotransposons mediate gene regulation in important developmental and pathological
processes. Here, we characterized the transient retrotransposon induction during …

[HTML][HTML] Tracing cell-type evolution by cross-species comparison of cell atlases

J Wang, H Sun, M Jiang, J Li, P Zhang, H Chen, Y Mei… - Cell Reports, 2021 - cell.com
Cell types are the basic building units of multicellular life, with extensive diversities. The
evolution of cell types is a crucial layer of comparative cell biology but is thus far not …

Imputing single-cell RNA-seq data by combining graph convolution and autoencoder neural networks

J Rao, X Zhou, Y Lu, H Zhao, Y Yang - Iscience, 2021 - cell.com
Single-cell RNA sequencing technology promotes the profiling of single-cell transcriptomes
at an unprecedented throughput and resolution. However, in scRNA-seq studies, only a low …

Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans

T Liu, J Li, L Yu, HX Sun, J Li, G Dong, Y Hu, Y Li… - Cell discovery, 2021 - nature.com
Interspecies blastocyst complementation enables organ-specific enrichment of xenogeneic
pluripotent stem cell (PSC) derivatives, which raises an intriguing possibility to generate …

Absolute quantification of microRNAs in a single cell with chemiluminescence detection based on rolling circle amplification on a microchip platform

S Chen, J Zhao, C Xu, IY Sakharov, S Zhao - Analytical chemistry, 2021 - ACS Publications
The absolute quantification of miRNAs in a single cell allows to better understand the
heterogeneity of cells and the relationship between miRNAs and diseases. However …