Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

The SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase
that plays a crucial role for a variety of different cellular functions. Besides balancing …

Aicardi-Goutières syndrome (AGS) is a monogenic type I interferonopathy characterized by
neurodevelopmental defects and upregulation of type I interferon signaling and …

Abstract Background Aicardi-Goutières syndrome (AGS) is a severe infant or juvenile-onset
autoimmune disease characterized by inflammatory encephalopathy with an elevated type 1 …

Preclinical studies on gene delivery into mouse lymphocytes are often hampered by
insufficient activity of lentiviral (LV) and adeno-associated vectors (AAVs) as well as missing …

MDA5 is a cytoplasmic sensor of viral RNA, triggering type I interferon (IFN-I) production.
Constitutively active MDA5 has been linked to autoimmune diseases such as systemic lupus …

Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of
cancer cells. Recently, a series of mutations in the multifunctional dNTP …

The availability and adequate balance of deoxyribonucleoside triphosphate (dNTP) is an
important determinant of both the fidelity and the processivity of DNA polymerases …

Autoimmune and autoinflammatory diseases are rare but often devastating disorders,
underpinned by abnormal immune function. While some autoimmune disorders are thought …

The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through
synthesis and degradation is critical for accurate genomic and mitochondrial DNA …