Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

The subgingival crevice harbors diverse microbial communities. Shifts in the composition of
these communities occur with the development of gingivitis and periodontitis, which are …

INTRODUCTION Mucosal barrier sites are continuously exposed to diverse environmental
stimuli, and the fine-tuning of mucosal tissue–specific immune responses is key to …

In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological
balance via both inter‐microbial and host‐microbial interactions that promote their own and …

Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …

Simple Summary Immunotherapy improved the therapeutic landscape for patients with
advanced cancer diseases. However, many patients do not benefit from immunotherapy …

Since 2010, next‐generation sequencing platforms have laid the foundation to an exciting
phase of discovery in oral microbiology as it relates to oral and systemic health and disease …

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and
for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly …

Periodontitis is a prevalent chronic disease that results in loss of periodontal ligament and
bone resorption. Triggered by pathogens and prolonged inflammation, periodontitis is …