Genetic polymorphism in olanzapine-metabolizing enzymes, transporters and drug targets is
associated with alterations in safety and efficacy. The aim of this systematic review is to …

Human genetics plays an increasingly important role in drug development and population
health. Here we review the history of human genetics in the context of accelerating the …

Genetic correlation analysis has quickly gained popularity in the past few years and
provided insights into the genetic etiology of numerous complex diseases. However, existing …

Different substance dependences have common effects on reward pathway and molecular
adaptations, however little is known regarding their shared genetic factors. We aimed to …

There is growing research interest in learning the genetic basis of response and adverse
effects with psychotropic medications, including antipsychotic drugs. However, the clinical …

BackgroundSchizophrenia is a severe and complex psychiatric disorder that needs
treatment based on extensive experience. Antipsychotic drugs have already become the …

Deletions and duplications of the distal region of the long arm of chromosome 1 are
associated with brain abnormalities and developmental delay. Because duplications are …