Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …

While young blood can restore many aged tissues, its effects on the aged blood system itself
and old hematopoietic stem cells (HSCs) have not been determined. Here, we used …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

Abstract Polo-like kinase 1 (PLK1) is an essential cell-cycle regulator that is frequently
overexpressed in various human cancers. To determine whether Plk1 overexpression drives …

Chromosome gains and losses are a frequent feature of human cancers. However, how
these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An …

Progeroid syndromes (PSs) are characterized by the premature onset of age-related
pathologies. The genetic mutations underlying PSs are functionally linked to genome …

Spermatogenesis is a cell differentiation process that ensures the production of fertilizing
sperm, which ultimately fuse with an egg to form a zygote. Normal spermatogenesis relies …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

One of the most curious findings emerged from genome-wide studies over the last decade
was that genetic mosaicism is a dominant feature of human ageing genomes. The clonal …