International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
[HTML][HTML] 5-HT receptors and temperature homeostasis
IP Voronova - Biomolecules, 2021 - mdpi.com
The present review summarizes the data concerning the influence of serotonin (5-HT)
receptors on body temperature in warm-blooded animals and on processes associated with …
receptors on body temperature in warm-blooded animals and on processes associated with …
[HTML][HTML] Current limitations and candidate potential of 5-HT7 receptor antagonism in psychiatric pharmacotherapy
R Okubo, T Hasegawa, K Fukuyama… - Frontiers in …, 2021 - frontiersin.org
Several mood-stabilizing atypical antipsychotics and antidepressants weakly block
serotonin (5-HT) receptor type-7 (5-HT7R); however, the contributions of 5-HT7R …
serotonin (5-HT) receptor type-7 (5-HT7R); however, the contributions of 5-HT7R …
[HTML][HTML] 5-HT7 receptors in Alzheimer's disease
Even though the involvement of serotonin (5-hydroxytryptamine; 5-HT) and its receptors in
Alzheimer's disease (AD) is widely accepted, data on the expression and the role of 5-HT 7 …
Alzheimer's disease (AD) is widely accepted, data on the expression and the role of 5-HT 7 …
[HTML][HTML] Effects of subchronic administrations of vortioxetine, lurasidone, and escitalopram on thalamocortical glutamatergic transmission associated with serotonin 5 …
M Okada, R Matsumoto, Y Yamamoto… - International journal of …, 2021 - mdpi.com
The functional suppression of serotonin (5-HT) type 7 receptor (5-HT7R) is forming a basis
for scientific discussion in psychopharmacology due to its rapid-acting antidepressant-like …
for scientific discussion in psychopharmacology due to its rapid-acting antidepressant-like …
Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor
Tauopathies comprise a heterogeneous family of neurodegenerative diseases
characterized by pathological accumulation of hyperphosphorylated Tau protein …
characterized by pathological accumulation of hyperphosphorylated Tau protein …
[HTML][HTML] Modulation of serotonin receptors in neurodevelopmental disorders: Focus on 5-HT7 receptor
J Lee, D Avramets, B Jeon, H Choo - Molecules, 2021 - mdpi.com
Since neurodevelopmental disorders (NDDs) influence more than 3% of children worldwide,
there has been intense investigation to understand the etiology of disorders and develop …
there has been intense investigation to understand the etiology of disorders and develop …
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263
We have previously reported that dual 5-HT 1A and 5-HT 7 receptor ligands might find utility
as treatment options for various CNS related conditions including cognitive and anxiolytic …
as treatment options for various CNS related conditions including cognitive and anxiolytic …
GPCR oligomerization as a target for antidepressants: focus on GPR39
At present most of the evidence for the relevance of oligomerization for the pharmacology of
depression comes from in vitro studies which identified oligomers, and from …
depression comes from in vitro studies which identified oligomers, and from …