The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

A Christofides, E Konstantinidou, C Jani, VA Boussiotis - Metabolism, 2021 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

H Choi, MC Rao, EB Chang - Nature Reviews Gastroenterology & …, 2021 - nature.com
Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …

Regulation of lipid metabolism by the unfolded protein response

M Moncan, K Mnich, A Blomme… - Journal of cellular …, 2021 - Wiley Online Library
The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …

PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

Lipodistrophy: a paradigm for understanding the consequences of “overloading” adipose tissue

K Lim, A Haider, C Adams, A Sleigh… - Physiological …, 2021 - journals.physiology.org
Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Icariin stimulates osteogenesis and suppresses adipogenesis of human bone mesenchymal stem cells via miR-23a-mediated activation of the Wnt/β-catenin signaling …

Y Xu, Y Jiang, B Jia, Y Wang, T Li - Phytomedicine, 2021 - Elsevier
Background Icariin (ICA) is a bioactive compound isolated from epimedium-derived
flavonoids that modulates bone mesenchymal stem cell osteogenesis and adipogenesis …

Targeted overexpression of PPARγ in skeletal muscle by random insertion and CRISPR/Cas9 transgenic pig cloning enhances oxidative fiber formation and …

H Gu, Y Zhou, J Yang, J Li, Y Peng, X Zhang… - The FASEB …, 2021 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPARγ) is a master regulator of
adipogenesis and lipogenesis. To understand its roles in fiber formation and fat deposition …

Effects of dietary lysine levels on growth performance, whole body composition and gene expression related to glycometabolism and lipid metabolism in grass carp …

D Huang, H Liang, M Ren, X Ge, K Ji, H Yu, S Maulu - Aquaculture, 2021 - Elsevier
Abstract 8 weeks rearing trial was designed to estimate the dietary lysine requirement, and
evaluate the effects of dietary lysine on glycometabolism and lipid metabolism of grass carp …

Epigenetic regulation of adipogenesis in development of metabolic syndrome

R Pant, P Firmal, VK Shah, A Alam… - Frontiers in Cell and …, 2021 - frontiersin.org
Obesity is one of the biggest public health concerns identified by an increase in adipose
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …

Xenoextracellular matrix-rosiglitazone complex-mediated immune evasion promotes xenogenic bioengineered root regeneration by altering M1/M2 macrophage …

T Lan, J Chen, J Zhang, F Huo, X Han, Z Zhang, Y Xu… - Biomaterials, 2021 - Elsevier
Xenogenic extracellular matrix (xECM)-based organ transplantation will be a promising
approach to address the problem of donor shortage for allotransplantation, which has …