Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …

Gitelman and Bartter syndromes are rare inherited diseases that belong to the category of
renal tubulopathies. The genes associated with these pathologies encode electrolyte …

Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide.
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …

The local environment forces a selection of bacteria that might invade the urinary tract,
allowing only the most virulent to access the kidney. Quite similar to the diet in setting the …

Uromodulin (UMOD) is a glycoprotein that is selectively expressed on the epithelial cells of
the thick ascending limb of Henle's loop and the early distal renal tubule. The present study …

Aim The phosphorylation level of the furosemide‐sensitive Na+‐K+‐2Cl− cotransporter
(NKCC2) in the thick ascending limb (TAL) is used as a surrogate marker for NKCC2 …

Spatial organization of molecules and cells in complex tissue microenvironments provides
essential organizational cues in health and disease. A significant need exists for improved …

Uromodulin is a nephrospecific protein that is most common in normal urine. And although it
has been known for more than 70 years, the function of uromodulin remains unclear …

І хоча він відомий більше 70 років, функція уромодуліну залишається до кінця не ясною.
Уромодулін бере участь у регулюванні транспорту солей, захищає від інфекцій …