Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl
modifications from lysine residues in various cellular targets including histones, transcription …

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …

Simple Summary Skin cancers (SC) are a frequent type of malignancy in white populations
and include malignant melanoma and non-melanoma skin cancer. Due to their increasing …

Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor that plays crucial roles in
several cellular processes. NAD can be synthesized de novo starting with tryptophan, or …

Increasing evidence confirms that sleep deprivation (SD), which induces hippocampal
neuroinflammation, is a risk factor for depression. Hydrogen sulfide (H 2 S) is a novel …

Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an
important role in the functioning of the body at the cellular level and participate in many …

The incidence of skin cancer has gradually increased in the last years and exposition to
ultraviolet radiation remains the main risk factor. We performed a comprehensive review on …

Perturbations in myocardial energy substrate metabolism are key contributors to the
pathogenesis of heart diseases. However, the underlying causes of these metabolic …