Combination therapy in inflammatory bowel disease–from traditional immunosuppressors towards the new paradigm of dual targeted therapy

G Privitera, D Pugliese, S Onali, V Petito… - Autoimmunity …, 2021 - Elsevier
Background Combining immunosuppressors has been proposed as a strategy to enhance
treatment efficacy in Inflammatory Bowel Disease (IBD). Aim To summarize current evidence …

IBD metabonomics predicts phenotype, disease course, and treatment response

JT Bjerrum, YL Wang, JB Seidelin, OH Nielsen - EBioMedicine, 2021 - thelancet.com
Metabonomics in inflammatory bowel disease (IBD) characterizes the effector molecules of
biological systems and thus aims to describe the molecular phenotype, generate insight into …

Dual targeted therapy: a possible option for the management of refractory inflammatory bowel disease

G Privitera, S Onali, D Pugliese, S Renna… - Journal of Crohn's …, 2021 - academic.oup.com
Abstract Background and Aims Dual targeted therapy [DTT] has been proposed as a novel
therapeutic strategy for the management of complicated patients with inflammatory bowel …

Ursolic acid regulates intestinal microbiota and inflammatory cell infiltration to prevent ulcerative colitis

Q Sheng, F Li, G Chen, J Li, J Li… - Journal of …, 2021 - Wiley Online Library
Ulcerative colitis (UC) is a chronic and relapsing inflammatory bowel disorder in the colon
and rectum leading to low life‐quality and high societal costs. Ursolic acid (UA) is a natural …

Anti-inflammatory activity of oat beta-glucans in a Crohn's disease model: Time-and molar mass-dependent effects

E Żyła, K Dziendzikowska, D Kamola, J Wilczak… - International Journal of …, 2021 - mdpi.com
Background: The incidence of Crohn's disease (CD) is increasing worldwide, and it has
currently become a serious public health issue in society. The treatment of CD continues …

Changes in the anterior cingulate cortex in Crohn's disease: a neuroimaging perspective

N Kong, C Gao, M Xu, X Gao - Brain and Behavior, 2021 - Wiley Online Library
Abstract Introduction Evidence suggests that Crohn's disease (CD) pathophysiology goes
beyond the gastrointestinal tract and is also strongly associated with the brain. In particular …

Potential of Phaleria macrocarpa leaves ethanol extract to upregulate the expression of caspase-3 in mouse distal colon after dextran sodium sulphate induction

K Kusmardi, E Wiyarta, A Estuningtyas, N Sahar… - Pharmacognosy …, 2021 - phcogj.com
Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained
importance over the past few decades. A lot of research has been done to find effective …

Treat-to-target approach in the management of inflammatory Bowel disease

P Nuñez, U Mahadevan, R Quera, C Bay… - … y Hepatología (English …, 2021 - Elsevier
With the advent of biologic and small molecule therapies, there has been a substantial
change in the treatment of inflammatory bowel disease. These advances have had a great …

Incidence of and risk factors for colorectal strictures in ulcerative colitis: a multicenter study

PA Laurain, L Guillo, F D'Amico, P Netter… - Clinical …, 2021 - Elsevier
Background & Aims Ulcerative colitis (UC) is increasingly recognized as a progressive
disease and patients with long-standing disease can develop colorectal stricture. Few data …

A random forest model predicts responses to infliximab in Crohn's disease based on clinical and serological parameters

Y Li, J Pan, N Zhou, D Fu, G Lian, J Yi… - Scandinavian Journal …, 2021 - Taylor & Francis
Background Infliximab (IFX) has revolutionised the treatment for Crohn's disease (CD)
recently, while a part of patients show no response to it at the end of the induction period …