[HTML][HTML] GLP-1 receptor agonists in the treatment of type 2 diabetes–state-of-the-art

MA Nauck, DR Quast, J Wefers, JJ Meier - Molecular metabolism, 2021 - Elsevier
Background GLP-1 receptor agonists (GLP-1 RAs) with exenatide bid first approved to treat
type 2 diabetes in 2005 have been further developed to yield effective compounds …

The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update

MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

[HTML][HTML] Regulation of postabsorptive and postprandial glucose metabolism by insulin-dependent and insulin-independent mechanisms: an integrative approach

GD Dimitriadis, E Maratou, A Kountouri, M Board… - Nutrients, 2021 - mdpi.com
Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

[HTML][HTML] Role of a dual glucose-dependent insulinotropic peptide (GIP)/glucagon-like peptide-1 receptor agonist (twincretin) in glycemic control: from pathophysiology …

MC Pelle, M Provenzano, I Zaffina, R Pujia, F Giofrè… - Life, 2021 - mdpi.com
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are two gut hormones, defined incretins, responsible for the amplification of insulin secretion …

[HTML][HTML] How glucagon-like peptide 1 receptor agonists work

CR Andreasen, A Andersen, FK Knop… - Endocrine …, 2021 - ec.bioscientifica.com
In recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central
in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with …

Patient initiation and maintenance of GLP-1 RAs for treatment of obesity

D Patel, A Smith - Expert Review of Clinical Pharmacology, 2021 - Taylor & Francis
ABSTRACT Introduction: Healthcare providers (HCPs) see many patients with obesity-
related complications and are therefore well placed to help treat obesity itself. However …

[HTML][HTML] Role of glucose-lowering medications in erectile dysfunction

A Cignarelli, VA Genchi, R D'Oria, F Giordano… - Journal of clinical …, 2021 - mdpi.com
Erectile dysfunction (ED) is a long-term complication of type 2 diabetes (T2D) widely known
to affect the quality of life. Several aspects of altered metabolism in individuals with T2D may …

Glucagonostatic potency of GLP-1 in patients with type 2 diabetes, patients with type 1 diabetes, and healthy control subjects

JI Bagger, MFG Grøndahl, A Lund, JJ Holst… - Diabetes, 2021 - Am Diabetes Assoc
Hyperglucagonemia is a well-known contributor to diabetic hyperglycemia, and glucagon-
like peptide 1 (GLP-1) suppresses glucagon secretion. Reduced inhibitory effects of glucose …

Role of glucagon-like peptide-1 (GLP-1) receptor agonists in hypoglycemia

D Ja'arah, MS Al Zoubi, G Abdelhady… - Clinical Medicine …, 2021 - journals.sagepub.com
A relatively recent addition to the arsenal of antidiabetic drugs used for the treatment of type
2 diabetes mellitus (T2DM) has been the “incretin mimetics,” a group of drugs that work on …

SGLT2i and GLP‐1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence

LD′ Marco, V Morillo, JL Gorriz… - Journal of Diabetes …, 2021 - Wiley Online Library
Background. Over the last few years, the use of sodium‐glucose cotransporter 2 inhibitors
(SGLT2i) and glucagon‐like peptide 1 receptor agonists (GLP‐1RA) has increased …