Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives
A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
Ranking biomarkers of aging by citation profiling and effort scoring
A Hartmann, C Hartmann, R Secci, A Hermann… - Frontiers in …, 2021 - frontiersin.org
Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …
survival. The chronological and the biological age of individuals can differ remarkably, and …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge
Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …
epidemiology and population science and have been proposed as surrogate measures for …
[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …
since their inception in 2013. Today, a variety of machine learning approaches have been …
Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood
Background Given associations linking early life adversity, pubertal timing, and biological
aging, we examined the direct and indirect effects of early life trauma on adult biological …
aging, we examined the direct and indirect effects of early life trauma on adult biological …
An integrative study of five biological clocks in somatic and mental health
Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …
more advanced in the presence of somatic illness and mental disorders. However, it is …
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
Genetic associations for two biological age measures point to distinct aging phenotypes
Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
Applying a life course biological age framework to improving the care of individuals with adult cancers: review and research recommendations
JS Mandelblatt, TA Ahles, ME Lippman, C Isaacs… - JAMA …, 2021 - jamanetwork.com
Importance The practice of oncology will increasingly involve the care of a growing
population of individuals with midlife and late-life cancers. Managing cancer in these …
population of individuals with midlife and late-life cancers. Managing cancer in these …