Chromatin structure and accessibility, and combinatorial binding of transcription factors to
regulatory elements in genomic DNA control transcription. Genetic variations in genes …

The age of onset of schizophrenia is related to variability in cognitive function and clinical
characters, and negative symptoms and cognitive function share similar features that could …

Much has been learned about the etiology and pathogenesis of schizophrenia since the
term was first used by Eugene Bleuler over a century ago to describe one of the most …

It has been suggested that dopaminergic neurotransmission plays important roles for the
psychotic symptoms and probably etiology of schizophrenia. In our recent preliminary study …

Background Striatal medium spiny neurons (MSNs) are preferentially lost in Huntington's
disease. Genomic studies also implicate a direct role for MSNs in schizophrenia, a …

Cannabis consumption during adolescence, increases the likelihood of adverse mental
health outcomes, including substance abuse and psychosis. Considering that part of the …

Many rare genetic syndromes are known to phenotypically manifest with psychiatric
symptoms that can be indistinguishable from primary psychiatric disorders. While the …

[eng] Psychotic disorders are psychiatric conditions with a worldwide prevalence of around
4% and a tremendous personal, economic and social burden. As complex phenotypes …

Mental illnesses are one of the biggest contributors to the global disease burden. Despite
the increased recognition, diagnosis and ongoing research of mental health disorders, the …