Management of pneumonia in critically ill patients

C Cillóniz, A Torres, MS Niederman - bmj, 2021 - bmj.com
Severe pneumonia is associated with high mortality (short and long term), as well as
pulmonary and extrapulmonary complications. Appropriate diagnosis and early initiation of …

Community-acquired pneumonia

S Aliberti, CSD Cruz, F Amati, G Sotgiu, MI Restrepo - The Lancet, 2021 - thelancet.com
Community-acquired pneumonia is not usually considered a high-priority problem by the
public, although it is responsible for substantial mortality, with a third of patients dying within …

Usefulness of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal …

Y Li, L Min, X Zhang - BMC Pulmonary Medicine, 2021 - Springer
Background There is a lack of studies comparing PCT, CRP and WBC levels in the
differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections. It …

Limited utility of procalcitonin in identifying community-associated bacterial infections in patients presenting with coronavirus disease 2019

M May, M Chang, D Dietz, S Shoucri… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The role of procalcitonin in identifying community-associated bacterial infections among
patients with coronavirus disease 2019 is not yet established. In 2,443 patients of whom 148 …

Discriminating bacterial and viral infection using a rapid host gene expression test

EL Tsalik, R Henao, JL Montgomery… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: Host gene expression signatures discriminate bacterial and viral infection but
have not been translated to a clinical test platform. This study enrolled an independent …

Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS

O Richards, P Pallmann, C King, Y Cheema, C Killick… - Antibiotics, 2021 - mdpi.com
Secondary bacterial infection in COVID-19 patients is associated with increased mortality
and disproportionately affects critically ill patients. This single-centre retrospective …

Host diagnostic biomarkers of infection in the ICU: where are we and where are we going?

AJ Heffernan, KJ Denny - Current infectious disease reports, 2021 - Springer
Abstract Purpose of Review Early identification of infection in the critically ill patient and
initiation of appropriate treatment is key to reducing morbidity and mortality. On the other …

Viral respiratory pathogens and lung injury

N Clementi, S Ghosh, M De Santis… - Clinical microbiology …, 2021 - Am Soc Microbiol
Several viruses target the human respiratory tract, causing different clinical manifestations
spanning from mild upper airway involvement to life-threatening acute respiratory distress …

Enhanced Detection of community-acquired pneumonia pathogens with the BioFire® Pneumonia FilmArray® Panel

DN Gilbert, JE Leggett, L Wang, S Ferdosian… - … and infectious disease, 2021 - Elsevier
Background Although most observational studies identify viral or bacterial pathogens in 50%
or less of patients hospitalized with community-acquired pneumonia (CAP), we previously …

BioFire® FilmArray® Pneumonia Panel for Severe Lower Respiratory Tract Infections: Subgroup Analysis of a Randomized Clinical Trial

E Kyriazopoulou, A Karageorgos… - Infectious Diseases and …, 2021 - Springer
Introduction The epidemiology of severe lower respiratory tract infections (LRTI) is constantly
changing. We aimed to describe it using the BioFire® FilmArray® Pneumonia plus (PN plus) …