The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …

Resident progenitor and/or stem cell populations in the adult adrenal cortex enable cortical
cells to undergo homeostatic renewal and regeneration after injury. Renewal occurs …

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of
ion channels or transporters. However, their frequency in aldosterone-producing cell …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

In response to physiological demand, the pituitary gland generates new hormone-secreting
cells from committed progenitor cells throughout life. It remains unclear to what extent …

The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its
functional capacity throughout life, the adrenal cortex must be continually replenished and …

Background Understanding the pathways that drive adrenocortical carcinoma (ACC) is
essential to the development of more effective therapies. This study investigates the role of …

The adrenal cortex is an endocrine organ organized into concentric zones that are
specialized to produce specific steroid hormones essential for life. The development and …

The Wnt signaling pathway is a critical mediator of the development and maintenance of
several tissues. The adrenal cortex is highly dependent upon Wnt/β-catenin signaling for …