Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Newer, more effective and non-cytotoxic therapies are an unmet need for patients with
diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. Recently approved …

Richter transformation (RT) is the development of aggressive lymphoma–most frequently
diffuse large B-cell lymphoma (DLBCL) and rarely Hodgkin lymphoma (HL)–arising on the …

Abstract In June 2020, the US Food and Drug Administration granted accelerated approval
to selinexor for the treatment of adult patients with relapsed or refractory diffuse large B-cell …

Introduction: Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma in
adults. 30–40% DLBCL eventually relapse and 10% are primary refractory, posing an unmet …

Purpose: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin
lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP …

Chromosome region maintenance 1 (CRM1) is a major nuclear export receptor protein and
contributes to cell homeostasis by mediating the transport of cargo from the nucleus to the …

The functionality of many tumor suppressor proteins (TSPs) and oncoprotein transcript RNAs
largely depend on their location within the cell. The exportin 1 complex (XPO1) transports …

Simple Summary JAK3 plays an important role in the pathogenesis of cutaneous T cell
lymphoma. JAK3 belongs to the Janus kinase family of receptor-associated tyrosine kinases …

Chimeric antigen receptor (CAR) T cells directed against CD19 (CD19. CAR T cells) have
yielded impressive clinical responses in the treatment of patients with lymphoid …