Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
DNA methylation-based age clocks: From age prediction to age reversion
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …
progressive decline in physiological functionality and enhanced disease vulnerability …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
Deep learning encodes robust discriminative neuroimaging representations to outperform standard machine learning
Recent critical commentaries unfavorably compare deep learning (DL) with standard
machine learning (SML) approaches for brain imaging data analysis. However, their …
machine learning (SML) approaches for brain imaging data analysis. However, their …
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge
Methods to quantify biological aging are emerging as new measurement tools for
epidemiology and population science and have been proposed as surrogate measures for …
epidemiology and population science and have been proposed as surrogate measures for …
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort
ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
Biological age in healthy elderly predicts aging-related diseases including dementia
Application of biological age as a measure of an individual´ s health status offers new
perspectives into extension of both lifespan and healthspan. While algorithms predicting …
perspectives into extension of both lifespan and healthspan. While algorithms predicting …
T cell fitness and autologous CAR T cell therapy in haematologic malignancy
PH Mehta, S Fiorenza, RM Koldej… - Frontiers in …, 2021 - frontiersin.org
A range of emerging therapeutic approaches for the treatment of cancer aim to induce or
augment endogenous T cell responses. Chimeric antigen receptor (CAR) T cell therapy …
augment endogenous T cell responses. Chimeric antigen receptor (CAR) T cell therapy …
Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2
Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species.
The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy …
The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy …
Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood
Background Given associations linking early life adversity, pubertal timing, and biological
aging, we examined the direct and indirect effects of early life trauma on adult biological …
aging, we examined the direct and indirect effects of early life trauma on adult biological …