Hygiene hypothesis and autoimmune diseases: A narrative review of clinical evidences and mechanisms

G Murdaca, M Greco, M Borro, S Gangemi - Autoimmunity Reviews, 2021 - Elsevier
Since the start of the “modern era”, characterized by the increase in urbanization, a
progressive attention to hygiene and autoimmune conditions has considerably grown …

Exploring the evidence for an immunomodulatory role of vitamin D in juvenile and adult rheumatic disease

J Zou, C Thornton, ES Chambers, EC Rosser… - Frontiers in …, 2021 - frontiersin.org
Vitamin D is synthesized in the skin following exposure to UVB radiation or is directly
absorbed from the diet. Following hydroxylation in the liver and kidneys, vitamin D becomes …

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram… - Cellular signalling, 2021 - Elsevier
The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

[HTML][HTML] The epidemiology of UK autoimmune liver disease varies with geographic latitude

GJ Webb, RP Ryan, TP Marshall… - Clinical Gastroenterology …, 2021 - Elsevier
Background & Aims The epidemiology of autoimmune liver disease (AILD) is challenging to
study because of the diseases' rarity and because of cohort selection bias. Increased …

[HTML][HTML] COVID-19 and the differences in physiological background between children and adults and their clinical consequences

L Kapustova, O Petrovicova, P Banovcin… - Physiological …, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 pandemic has indeed been one of the most significant problems facing
the world in the last decade. It has affected (directly or indirectly) the entire population and …

Non-classical effects of vitamin D: Non-bone effects of vitamin D

AG Lopez, V Kerlan, R Desailloud - Annales d'endocrinologie, 2021 - Elsevier
Our understanding of vitamin D has improved considerably in recent years. The role of
vitamin D in preventing osteoporotic fractures is now well-established. However, an …

Possible roles of permafrost melting, atmospheric transport, and solar irradiance in the development of major coronavirus and influenza pandemics

AM Hofmeister, JM Seckler, GM Criss - International Journal of …, 2021 - mdpi.com
Major pandemics involving respiratory viruses develop semi-regularly and require a large
flux of novel viruses, yet their origination is equivocal. This paper explores how natural …

Vitamin d metabolic pathway genes polymorphisms and their methylation levels in association with rheumatoid arthritis

TP Zhang, HM Li, Q Huang, L Wang, XM Li - Frontiers in immunology, 2021 - frontiersin.org
Abnormal vitamin D metabolism is involved in the pathogenesis of rheumatoid arthritis (RA).
In this study, we evaluated the association of single nucleotide polymorphisms (SNPs) and …

Vitamin D levels are associated with disease activity and damage accrual in systemic lupus erythematosus patients

M Correa-Rodríguez… - Biological Research …, 2021 - journals.sagepub.com
Vitamin D has immunosuppressive properties and is considered a therapeutic option,
although there is controversy about the role of this vitamin in the pathogenesis of systemic …

Vitamin D, autoimmunity and immune-related adverse events of immune checkpoint inhibitors

L Sun, J Arbesman, M Piliang - Archives of Dermatological Research, 2021 - Springer
In addition to its quintessential role in bone homeostasis, vitamin D also plays an important
role in regulating the immune system. As such, many studies have demonstrated the …