The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract

Y Shi, L Shuai, Z Wen, C Wang, Y Yan… - Emerging Microbes & …, 2021 - Taylor & Francis
The unprecedented coronavirus disease 2019 (COVID-19) pandemic, caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a serious threat to global public …

Identification of an intramolecular switch that controls the interaction of helicase nsp10 with membrane-associated nsp12 of porcine reproductive and respiratory …

Y Hu, P Ke, P Gao, Y Zhang, L Zhou, X Ge… - Journal of …, 2021 - Am Soc Microbiol
ABSTRACT A critical step in replication of positive-stranded RNA viruses is the assembly of
replication and transcription complexes (RTC). We have recently mapped the nonstructural …