Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism

CC Anderson, JO Marentette, KM Prutton… - Free Radical Biology …, 2021 - Elsevier
Down syndrome (DS) is the most common genetic cause of intellectual disability.
Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological …

Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse

D Szwajgier, E Baranowska-Wójcik… - Disease …, 2021 - Wiley Online Library
Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene
dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we …

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma

K Manabe, S Kaidzu, A Tsutsui, M Mochiji… - Journal of Clinical …, 2021 - jstage.jst.go.jp
抄録 We tested oral French maritime pine bark (40 mg)/bilberry fruit extract (90 mg)
supplements for intraocular pressure-lowering effects in Japanese subjects with primary …

[HTML][HTML] Serum Reactive Oxygen Metabolites as a Predictor of Clinical Disease Activity Index, Simplified Disease Activity Index, and Boolean Remissions in …

A Nakajima, K Terayama, M Sonobe, Y Akatsu, J Saito… - Cureus, 2021 - ncbi.nlm.nih.gov
Materials and methods Fifty-one biologic agents (BA)-naïve RA patients were included in
this observational study. Associations between ROMs, C-reactive protein, matrix …

Clinical Significance of Serum Levels of ROM (Reactive Oxygen Metabolites) in Patients With Rheumatoid Arthritis Treated With Biologic Agents as a Predictor for the …

A Nakajima, K Terayama, M Sonobe, Y Akatsu, J Saito… - 2021 - researchsquare.com
We previously showed that reactive oxygen metabolites (ROM) serum levels were
associated with the DAS28 in patients with rheumatoid arthritis (RA). In this study, we aimed …