Breast cancer stands as the most prevalent cancer in women globally, and contributes to the
highest percentage of mortality due to cancer-related deaths in women. Paclitaxel (PTX) is …

Tumor cells mainly provide necessary energy and substances for rapid cell growth through
aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the …

Natural products and their derivatives are important sources for drug discovery; however,
they usually have poor solubility and low activity and require structural modification. Amino …

Simple Summary Since the role of immune evasion was included as a hallmark in cancer,
the idea of cancer as a single cell mass that replicate unlimitedly in isolation was dissolved …

Shikonin, a natural product isolated from the roots of Lithospermum erythrorhizon, exhibits
pharmacological effects against inflammation, ulcers, infections, and tumors. In the present …

Signal transducer and activator of transcription 3 (STAT3) activation is associated with drug
resistance induced by anti‑epidermal growth factor receptor (anti‑EGFR) therapy in the …

Shikonin is one of the major bioactive components of Lithospermum erythrorhizon. It has a
good killing effect in a variety of tumor cells. Its antitumor effect involves multiple targets and …

Pneumonia is an inflammatory disease induced by infection with different pathogens.
Currently, multiple preclinical studies have revealed that shikonin, a natural …

Background In-feed antibiotics are being phased out in livestock production worldwide.
Alternatives to antibiotics are urgently needed to maintain animal health and production …

Melanoma is the deadliest form of skin cancer and accounts for about three quarters of all
skin cancer deaths. Especially at an advanced stage, its treatment is challenging, and …