The prescribing and use of opioid analgesics is increasing in Italy owing to a profusion in the
number and types of opioid analgesic products available, and the increasing prevalence of …

In treating chronic and acute pain, opioids are widely used. Although they do provide
analgesia, their usage does come with adverse events (AEs). One of the most burdensome …

Background Tapentadol is a combined opioid agonist and norepinephrine reuptake inhibitor
with fewer gastrointestinal side effects at equianalgesic doses compared with classical …

Chronic constipation (CC) is a gastrointestinal disorder that adversely affects the quality of
life. MicroRNAs are involved in the pathogenesis of functional gastrointestinal disorders …

Among all the side effects, opioid-induced constipation (OIC) has the highest incidence rate
in people who take chronic opioid therapy. Increasing evidence shows that enteric glial cells …

Background Pain therapy in inpatients is regularly suboptimal and might be improved by
clinical pharmacy services. In our hospital, we have implemented a software‐supported …

Constipation and abdominal pain are commonly encountered in opioid-induced bowel
dysfunction (OBD). The underlying mechanisms are incompletely understood, and …

Simple Summary The frequent use of opioid in-home palliative care settings is associated
with a high incidence of opioid-induced constipation (OIC) that can significantly worsen a …

Constipation is a common disease that reduces life quality. Drugs of various mechanisms
are being developed to resolve this affliction. Intestinal motility can be easily monitored in …

Naldemedine is the newest orally available, peripherally selective μ-opioid receptor
antagonist blocker approved for opioid-induced constipation (OIC) treatment in adult …