Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

Attenuating the effects of novel COVID-19 (SARS-CoV-2) infection-induced cytokine storm and the implications

AB Rowaiye, OA Okpalefe… - Journal of …, 2021 - Taylor & Francis
The COVID-19 pandemic constitutes an arduous global health challenge, and the
increasing number of fatalities calls for the speedy pursuit of a remedy. This review …

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Y Zhao, L Sui, P Wu, W Wang, Z Wang, Y Yu… - … and Targeted Therapy, 2021 - nature.com
The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …

Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter cytokine …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …

Disrupted resolution mechanisms favor altered phagocyte responses in COVID-19

DS Koenis, I Beegun, CC Jouvene, GA Aguirre… - Circulation …, 2021 - Am Heart Assoc
Rationale: Resolution mechanisms are central in both the maintenance of homeostasis and
the return to catabasis following tissue injury and infections. Among the proresolving …

Therapeutic potential of resveratrol in COVID-19-associated hemostatic disorders

R Giordo, A Zinellu, AH Eid, G Pintus - Molecules, 2021 - mdpi.com
Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks
in SARS-CoV-2 infection, largely determining COVID-19's outcome and severity …

Eosinophils and COVID-19: diagnosis, prognosis, and vaccination strategies

HF Rosenberg, PS Foster - Seminars in immunopathology, 2021 - Springer
The unprecedented impact of the coronavirus disease 2019 (COVID-19) pandemic has
resulted in global challenges to our health-care systems and our economic security. As …

Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation

C Zhang, X Wang, C Wang, C He, Q Ma, J Li… - Frontiers in …, 2021 - frontiersin.org
Background: Acute lung injury (ALI) is characterized by dysfunction of the alveolar epithelial
membrane caused by acute inflammation and tissue injury. Qingwenzhike (QWZK) …

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2

A Gour, D Manhas, S Bag, B Gorain… - Phytotherapy …, 2021 - Wiley Online Library
Emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection,
COVID‐19, has become the global panic since December 2019, which urges the global …

Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the
worst possible scenarios is represented by the critical lung damage caused by the severe …