Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions
Protein–protein interactions are fundamental to various aspects of cell biology with many
protein complexes participating in numerous fundamental biological processes such as …
protein complexes participating in numerous fundamental biological processes such as …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
hu. MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies
A general principle of biology is the self‐assembly of proteins into functional complexes.
Characterizing their composition is, therefore, required for our understanding of cellular …
Characterizing their composition is, therefore, required for our understanding of cellular …
Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery
In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …
interactome network to predict novel putative disease genes and modules. We first apply the …
Human paraoxonase-2 (PON2): protein functions and modulation
G Manco, E Porzio, TM Carusone - Antioxidants, 2021 - mdpi.com
PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or
proteomic features in involved tissues that define pathobiological differences between …
proteomic features in involved tissues that define pathobiological differences between …
Characterizing endogenous protein complexes with biological mass spectrometry
R Rogawski, M Sharon - Chemical reviews, 2021 - ACS Publications
Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …
Meta-analysis defines principles for the design and analysis of co-fractionation mass spectrometry experiments
MA Skinnider, LJ Foster - Nature Methods, 2021 - nature.com
Co-fractionation mass spectrometry (CF-MS) has emerged as a powerful technique for
interactome mapping. However, there is little consensus on optimal strategies for the design …
interactome mapping. However, there is little consensus on optimal strategies for the design …
Revealing protein-protein interactions at the transcriptome scale by sequencing
We describe PROPER-seq (protein-protein interaction sequencing) to map protein-protein
interactions (PPIs) en masse. PROPER-seq first converts transcriptomes of input cells into …
interactions (PPIs) en masse. PROPER-seq first converts transcriptomes of input cells into …