Quantifying the contribution of Neanderthal introgression to the heritability of complex traits
Abstract Eurasians have~ 2% Neanderthal ancestry, but we lack a comprehensive
understanding of the genome-wide influence of Neanderthal introgression on modern …
understanding of the genome-wide influence of Neanderthal introgression on modern …
Polygenic risk scores: the future of cancer risk prediction, screening, and precision prevention
Y Wang, M Zhu, H Ma, H Shen - Medical Review, 2021 - degruyter.com
Genome-wide association studies (GWASs) have shown that the genetic architecture of
cancers are highly polygenic and enabled researchers to identify genetic risk loci for …
cancers are highly polygenic and enabled researchers to identify genetic risk loci for …
Dissecting the heritable risk of breast cancer: from statistical methods to susceptibility genes
Decades of research have shown that rare highly penetrant mutations can promote
tumorigenesis, but it is still unclear whether variants observed at high-frequency in the …
tumorigenesis, but it is still unclear whether variants observed at high-frequency in the …
[PDF][PDF] Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data
The proportion of variation in complex traits that can be attributed to non-additive genetic
effects has been a topic of intense debate. The availability of biobank-scale datasets of …
effects has been a topic of intense debate. The availability of biobank-scale datasets of …
Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
The number of variants that have a non-zero effect on a trait (ie. polygenicity) is a
fundamental parameter in the study of the genetic architecture of a complex trait. Although …
fundamental parameter in the study of the genetic architecture of a complex trait. Although …
GxEsum: a novel approach to estimate the phenotypic variance explained by genome-wide GxE interaction based on GWAS summary statistics for biobank-scale data
Genetic variation in response to the environment, that is, genotype-by-environment
interaction (GxE), is fundamental in the biology of complex traits and diseases. However …
interaction (GxE), is fundamental in the biology of complex traits and diseases. However …
Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits
We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability
estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 …
estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 …
External validation of integrated genetic-epigenetic biomarkers for predicting incident coronary heart disease
Aim: The Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease
(ASCVD) Pooled Cohort Equation (PCE) for predicting risk for incident coronary heart …
(ASCVD) Pooled Cohort Equation (PCE) for predicting risk for incident coronary heart …
Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis
While recent advancements in computation and modelling have improved the analysis of
complex traits, our understanding of the genetic basis of the time at symptom onset remains …
complex traits, our understanding of the genetic basis of the time at symptom onset remains …
Evaluation of modifiable factors and polygenic risk score in thyroid cancer
The cumulative effect of single-nucleotide polymorphisms (SNPs) on thyroid cancer has
been adequately defined in individuals of European ancestry; however, similar evidence in …
been adequately defined in individuals of European ancestry; however, similar evidence in …