Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions

JD Lasso, DJ Castillo-Pazos, CJ Li - Chemical Society Reviews, 2021 - pubs.rsc.org
The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …

[HTML][HTML] Glutathione participation in the prevention of cardiovascular diseases

D Matuz-Mares, H Riveros-Rosas… - Antioxidants, 2021 - mdpi.com
Cardiovascular diseases (CVD)(such as occlusion of the coronary arteries, hypertensive
heart diseases and strokes) are diseases that generate thousands of patients with a high …

Antioxidant responses of the mussel Mytilus coruscus co-exposed to ocean acidification, hypoxia and warming

FU Khan, H Chen, H Gu, T Wang, S Dupont… - Marine Pollution …, 2021 - Elsevier
In the present study, the combined effects of pH, dissolved oxygen (DO) and temperature
levels on the antioxidant responses of the mussel Mytilus coruscus were evaluated. Mussels …

Meso-pyridinium substituted BODIPY dyes as mitochondria-targeted probes for the detection of cysteine in living cells and in vivo

X Ji, N Wang, J Zhang, S Xu, Y Si, W Zhao - Dyes and Pigments, 2021 - Elsevier
Cysteine (Cys) is a crucial bio-thiol attributing to its significant role in many physiological and
pathological processes and maintaining redox dynamic balance. In mitochondria, ROS can …

[HTML][HTML] Lumbriculus variegatus (oligochaeta) exposed to polyethylene microplastics: biochemical, physiological and reproductive responses

CJM Silva, ALP Silva, D Campos, AMVM Soares… - Ecotoxicology and …, 2021 - Elsevier
Freshwater sediments are a repository of microplastics (MPs) resulting from inland
anthropogenic activities. Benthic invertebrates, particularly endobenthic sediment–ingesting …

A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease

S Mani, M Sevanan, A Krishnamoorthy, S Sekar - Neurological Sciences, 2021 - Springer
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that
affects 1% of the population worldwide. Etiology of PD is likely to be multi-factorial such as …

Eugenol attenuates TiO2 nanoparticles-induced oxidative damage, biochemical toxicity and DNA damage in Wistar rats: an in vivo study

MR Wani, N Maheshwari, G Shadab - Environmental Science and …, 2021 - Springer
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in food, edible dyes,
and other commercial products. Human exposure to TiO 2 NPs has raised concerns …

[HTML][HTML] Ferroptosis is a potential novel diagnostic and therapeutic target for patients with cardiomyopathy

Z Zhai, P Zou, F Liu, Z Xia, J Li - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Cardiomyocyte death is a fundamental progress in cardiomyopathy. However, the
mechanism of triggering the death of myocardial cells remains unclear. Ferroptosis, which is …

Simultaneous determination of DL-cysteine, DL-homocysteine, and glutathione in saliva and urine by UHPLC-Q-Orbitrap HRMS: Application to studies of oxidative …

Q Ma, C Qi, XL Li, Q Shi, CY Xu, T Jin, JZ Min - Journal of Pharmaceutical …, 2021 - Elsevier
A high-sensitivity and-selectivity mass spectrometry derivatization reagent,(R)-(5-(3-
isothiocyanatopyrrolidin-1-yl)-5-oxopentyl) triphenylphosphonium (NCS-OTPP), was …

[HTML][HTML] Are Microplastics Impairing Marine Fish Larviculture?—Preliminary Results with Argyrosomus regius

D Campos, ACM Rodrigues, RJM Rocha, R Martins… - Water, 2021 - mdpi.com
The presence of small-sized (< 300 µm) microplastics (MPs) in aquaculture facilities may
threaten finfish hatchery, as their (in) voluntary ingestion by fish larvae may compromise …