[PDF][PDF] Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology

VJ Sydnor, B Larsen, DS Bassett, A Alexander-Bloch… - Neuron, 2021 - cell.com
The human brain undergoes a prolonged period of cortical development that spans multiple
decades. During childhood and adolescence, cortical development progresses from lower …

Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …

Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for developing psychosis: an ENIGMA working …

M Jalbrzikowski, RA Hayes, SJ Wood… - JAMA …, 2021 - jamanetwork.com
Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

[HTML][HTML] Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

A Gialluisi, TFM Andlauer, N Mirza-Schreiber… - Molecular …, 2021 - nature.com
Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a
heritability of 40–60%. A notable part of this heritability remains unexplained, and large …

Causal associations between modifiable risk factors and the Alzheimer's phenome

SJ Andrews, B Fulton‐Howard, P O'Reilly… - Annals of …, 2021 - Wiley Online Library
Objective The purpose of this study was to infer causal relationships between 22 previously
reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of …

Educational attainment does not influence brain aging

L Nyberg, F Magnussen, A Lundquist… - Proceedings of the …, 2021 - National Acad Sciences
Education has been related to various advantageous lifetime outcomes. Here, using
longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis …

Shared heritability of human face and brain shape

S Naqvi, Y Sleyp, H Hoskens, K Indencleef… - Nature Genetics, 2021 - nature.com
Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …

[HTML][HTML] Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

LKM Han, R Dinga, T Hahn, CRK Ching, LT Eyler… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

[HTML][HTML] The genetic architecture of structural left–right asymmetry of the human brain

Z Sha, D Schijven, A Carrion-Castillo, M Joliot… - Nature human …, 2021 - nature.com
Left–right hemispheric asymmetry is an important aspect of healthy brain organization for
many functions including language, and it can be altered in cognitive and psychiatric …

[PDF][PDF] Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis

N Aygün, AL Elwell, D Liang, MJ Lafferty… - The American Journal of …, 2021 - cell.com
Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …