Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical Reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Recent research and development of NDM-1 inhibitors
T Wang, K Xu, L Zhao, R Tong, L Xiong, J Shi - European journal of …, 2021 - Elsevier
Abstract Bacteria carrying New Delhi metallo-β-lactamase-1 (New Delhi metallo-β-
lactamase, NDM-1) resistance gene is a new type of “superbug”, which can hydrolyze …
lactamase, NDM-1) resistance gene is a new type of “superbug”, which can hydrolyze …
Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)
KCN Venkata, M Ellebrecht, SK Tripathi - European journal of medicinal …, 2021 - Elsevier
Antimicrobial stewardship is imperative when treating bacterial infections because the
misuse and overuse of antibiotics have caused pathogens to develop life-threatening …
misuse and overuse of antibiotics have caused pathogens to develop life-threatening …
Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors
Abstract β-lactam antibiotics have long been the mainstay for the treatment of bacterial
infections. New Delhi metallo-β-lactamase 1 (NDM-1) is able to hydrolyze nearly all β-lactam …
infections. New Delhi metallo-β-lactamase 1 (NDM-1) is able to hydrolyze nearly all β-lactam …
[HTML][HTML] Enzyme inhibitors: the best strategy to tackle superbug NDM-1 and its variants
X Li, D Zhao, W Li, J Sun, X Zhang - International Journal of Molecular …, 2021 - mdpi.com
Multidrug bacterial resistance endangers clinically effective antimicrobial therapy and
continues to cause major public health problems, which have been upgraded to …
continues to cause major public health problems, which have been upgraded to …
Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition
Abstract Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that
inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems …
inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems …
Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota
H Liu, Y Qin, K Li, M Li, J Yang, H Tao… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Gut microbiota plays an important role in type 2 diabetes mellitus
(T2DM) progression. From our previous work N‐(4‐Hydroxyphenethyl)‐3‐mercapto‐2 …
(T2DM) progression. From our previous work N‐(4‐Hydroxyphenethyl)‐3‐mercapto‐2 …
Molecular docking studies, in-silico ADMET predictions and synthesis of novel PEGA-nucleosides as antimicrobial agents targeting class B1 metallo-β-lactamases
JA Mendoza, RY Pineda, M Nguyen, M Tellez… - In Silico …, 2021 - Springer
Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria.
The enzyme requires zinc ions, along with conserved amino acid coordination for …
The enzyme requires zinc ions, along with conserved amino acid coordination for …
Synthesis of 1, 3, 4-trisubstituted pyrrolidines as meropenem adjuvants targeting New Delhi metallo-β-lactamase
The effective strategies to neutralize the New Delhi metallo-β-lactamase (NDM-1) activity
offer unique opportunities to combination therapy because NDM-1 inactivates all classes of …
offer unique opportunities to combination therapy because NDM-1 inactivates all classes of …
Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study
D Zhao, H Li, C Yue, K Sun, Y Dai, H Zhang… - Journal of Inorganic …, 2021 - Elsevier
This study investigated whether captopril can reverse drug resistance in metallo-β-
lactamase (MBL)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and …
lactamase (MBL)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and …