In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

We envisage the development of new Brain Health Services to achieve primary and
secondary dementia prevention. These services will complement existing memory clinics by …

Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

Dementia is a highly heterogeneous condition, with pronounced individual differences in
age of onset, clinical presentation, progression rates and neuropathological hallmarks, even …

Background Air quality contributes to incidence of Alzheimer's disease (AD) although the
underlying neurobiological mechanisms are unclear. This study was aimed to examine the …

Introduction Evidence on sex differences in the risk for dementia has been mixed. The goal
was to assess sex differences in the development of dementia, and in the effects of a lifestyle …

Importance Understanding mechanisms associated with prolonged cognitive health in
combination with exceptional longevity might lead to approaches to enable successful …