The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function stability and well-being. ECM detachment in localized tumors precedes abnormal …
The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target …
Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die, partly because they experience oxidative stress. Metastasizing cancer cells migrate through …
SY Loo, LP Toh, WH Xie, E Pathak, W Tan, S Ma… - Science …, 2021 - science.org
Cell state transitions control the functional behavior of cancer cells. Epithelial-to- mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced …
M Bacci, N Lorito, A Smiriglia, A Morandi - Trends in cancer, 2021 - cell.com
Lipid metabolic reprogramming is an established trait of cancer metabolism that guides response and resistance to antitumoral therapies. Enhanced lipogenesis, increased lipid …
M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …
Strengthening the gut epithelial barrier is a potential strategy for management of gut microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 …
Pancreatic ductal adenocarcinoma (PDAC) metastasizes to distant organs, which is the primary cause of mortality; however, specific features mediating organ-specific metastasis …
S Chen, J Gu, Q Zhang, Y Hu, Y Ge - Journal of oncology, 2021 - Wiley Online Library
Purpose. To generate a signature based on anoikis‐related genes (ARGs) for endometrial carcinoma (EC) patients and elucidate the molecular mechanisms in EC. Methods. On the …