The metabolism of cancer cells during metastasis

G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

[HTML][HTML] Mechanisms for modulating anoikis resistance in cancer and the relevance of metabolic reprogramming

FO Adeshakin, AO Adeshakin, LO Afolabi, D Yan… - Frontiers in …, 2021 - frontiersin.org
The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

Emerging strategies for treating metastasis

M Esposito, S Ganesan, Y Kang - Nature cancer, 2021 - nature.com
The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

Redox regulation in cancer cells during metastasis

A Tasdogan, JM Ubellacker, SJ Morrison - Cancer discovery, 2021 - AACR
Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die,
partly because they experience oxidative stress. Metastasizing cancer cells migrate through …

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

SY Loo, LP Toh, WH Xie, E Pathak, W Tan, S Ma… - Science …, 2021 - science.org
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-
mesenchymal transition (EMT) confers cancer stem cell-like properties, enhanced …

Fat and furious: lipid metabolism in antitumoral therapy response and resistance

M Bacci, N Lorito, A Smiriglia, A Morandi - Trends in cancer, 2021 - cell.com
Lipid metabolic reprogramming is an established trait of cancer metabolism that guides
response and resistance to antitumoral therapies. Enhanced lipogenesis, increased lipid …

[HTML][HTML] Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy

M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

[PDF][PDF] Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice

CS Chang, YC Liao, CT Huang, CM Lin, CHY Cheung… - Cell Reports, 2021 - cell.com
Strengthening the gut epithelial barrier is a potential strategy for management of gut
microbiota-associated illnesses. Here, we demonstrate that dual-specificity phosphatase 6 …

Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma

RK Nimmakayala, F Leon, S Rachagani, S Rauth… - Oncogene, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) metastasizes to distant organs, which is the
primary cause of mortality; however, specific features mediating organ-specific metastasis …

Development of biomarker signatures associated with anoikis to predict prognosis in endometrial carcinoma patients

S Chen, J Gu, Q Zhang, Y Hu, Y Ge - Journal of oncology, 2021 - Wiley Online Library
Purpose. To generate a signature based on anoikis‐related genes (ARGs) for endometrial
carcinoma (EC) patients and elucidate the molecular mechanisms in EC. Methods. On the …