A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Networks effectively capture interactions among components of complex systems, and have
thus become a mainstay in many scientific disciplines. Growing evidence, especially from …

Genome-wide loss-of-function screens have revealed genes essential for cancer cell
proliferation, called cancer dependencies. It remains challenging to link cancer …

CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of
function causes cell death or loss of fitness or, more rarely, the opposite phenotype of faster …

Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint
blockade despite significant frequencies of exhausted T cells. Here we apply mass …

Genetic coessentiality analysis, a computational approach which identifies genes sharing a
common effect on cell fitness across large-scale screening datasets, has emerged as a …

Background With the advent of large-scale molecular profiling, an increasing number of
oncogenic drivers contributing to precise medicine and reshaping classification of lung …

Detoxification enzymes are necessary for insects to metabolize toxic substances and
maintain physiological activities. Cytochromes P450 (CYPs), glutathione S‐transferases …

Motivation Differential network analysis is an important tool to investigate the rewiring of
gene interactions under different conditions. Several computational methods have been …

Systems biology is a data-heavy field that focuses on systems-wide depictions of biological
phenomena necessarily sacrificing a detailed characterization of individual components. As …