Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human
genome to estimate the risk of a disease or disease-related trait for an individual. The …

The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …

The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …

Background: We established a community-based cohort study to assess the long-term
impact of the Great East Japan Earthquake on disaster victims and gene-environment …

Debiased inverse-variance weighted estimator in two-sample summary-data Mendelian
randomization Page 1 The Annals of Statistics 2021, Vol. 49, No. 4, 2079–2100 https://doi.org/10.1214/20-AOS2027 …

Over a decade of genome-wide association studies (GWAS) have led to the finding of
extreme polygenicity of complex traits. The phenomenon that “all genes affect every complex …

Importance Obesity is associated with a higher risk of cardiovascular disease (CVD), but
little is known about the role that circulating protein biomarkers play in this association …

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with complex traits, including a wide variety of diseases. Despite the successful …

Preferential fat accumulation in visceral vs. subcutaneous depots makes obese individuals
more prone to metabolic complications. Body fat distribution (FD) is regulated by genetics …