Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment
S Boopathi, AB Poma, P Kolandaivel - Journal of Biomolecular …, 2021 - Taylor & Francis
In the past two decades, the world has faced several infectious disease outbreaks. Ebola,
Influenza A (H1N1), SARS, MERS, and Zika virus have had a massive global impact in terms …
Influenza A (H1N1), SARS, MERS, and Zika virus have had a massive global impact in terms …
Potential SARS-CoV-2 main protease inhibitors
R Banerjee, L Perera, LMV Tillekeratne - Drug Discovery Today, 2021 - Elsevier
Highlights•The SARS-CoV-2 main protease is a prime drug target.•Coronavirus main
proteases share a structurally conserved substrate-binding region.•The structure and …
proteases share a structurally conserved substrate-binding region.•The structure and …
Exploring the binding mechanism of PF-07321332 SARS-CoV-2 protease inhibitor through molecular dynamics and binding free energy simulations
The novel coronavirus disease, caused by severe acute respiratory coronavirus 2 (SARS-
CoV-2), rapidly spreading around the world, poses a major threat to the global public health …
CoV-2), rapidly spreading around the world, poses a major threat to the global public health …
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2
A Du, R Zheng, C Disoma, S Li, Z Chen, S Li… - International journal of …, 2021 - Elsevier
SARS-CoV-2 is the etiological agent responsible for the ongoing pandemic of coronavirus
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
[PDF][PDF] Antivirals with common targets against highly pathogenic viruses
Historically, emerging viruses appear constantly and have cost millions of human lives.
Currently, climate change and intense globalization have created favorable conditions for …
Currently, climate change and intense globalization have created favorable conditions for …
Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugs
Abstract Background The main protease (Mpro) of SARS-CoV-2 is involved in the
processing of vital polypeptides required for viral genome replication and transcription and …
processing of vital polypeptides required for viral genome replication and transcription and …
What coronavirus 3C‐like protease tells us: from structure, substrate selectivity, to inhibitor design
M Xiong, H Su, W Zhao, H Xie… - Medicinal Research …, 2021 - Wiley Online Library
The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
A comprehensive review about the molecular structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Insights into natural products against …
In 2019, the world suffered from the emergence of COVID-19 infection, one of the most
difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have …
difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have …
Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study
N Sepay, A Sekar, UC Halder, A Alarifi… - Journal of molecular …, 2021 - Elsevier
Traditional medicines contain natural products (NPs) as main ingredient which always give
new direction and paths to develop new advanced medicines. In the COVID-19 pandemic …
new direction and paths to develop new advanced medicines. In the COVID-19 pandemic …
[HTML][HTML] In silico investigation of potential inhibitors to main protease and spike protein of SARS-CoV-2 in propolis
AH Harisna, R Nurdiansyah, PH Syaifie… - … and Biophysics Reports, 2021 - Elsevier
Docking analysis of propolis's natural compound was successfully performed against SARS-
CoV-2 main protease (Mpro) and spike protein subunit 2 (S2). Initially, the propolis's protein …
CoV-2 main protease (Mpro) and spike protein subunit 2 (S2). Initially, the propolis's protein …