Genetics of obesity: what we have learned over decades of research
C Bouchard - Obesity, 2021 - Wiley Online Library
There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …
variability in body weight status but that is lower among normal weight individuals (about …
Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease
V Barrios, JA Chowen, Á Martín-Rivada… - Cells, 2021 - mdpi.com
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles
during development, maturation, and aging. Members of this axis, composed of various …
during development, maturation, and aging. Members of this axis, composed of various …
MC3R links nutritional state to childhood growth and the timing of puberty
The state of somatic energy stores in metazoans is communicated to the brain, which
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
The resources generated by the GTEx consortium offer unprecedented opportunities to
advance our understanding of the biology of human diseases. Here, we present an in-depth …
advance our understanding of the biology of human diseases. Here, we present an in-depth …
Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
Exome association studies to date have generally been underpowered to systematically
evaluate the phenotypic impact of very rare coding variants. We leveraged extensive …
evaluate the phenotypic impact of very rare coding variants. We leveraged extensive …
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance
Y He, AE Gallman, C Xie, Q Shen, J Ma… - Journal of Experimental …, 2021 - rupress.org
B cell self-tolerance is maintained through multiple checkpoints, including restraints on
intracellular signaling and cell trafficking. P2RY8 is a receptor with established roles in …
intracellular signaling and cell trafficking. P2RY8 is a receptor with established roles in …
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption
B Kespohl, T Schumertl, J Bertrand, J Lokau… - Cytokine & growth factor …, 2021 - Elsevier
Bone development is a complex process that requires the activity of several different
signaling pathways and cell types. It involves the coordinated action of osteoclasts (cells that …
signaling pathways and cell types. It involves the coordinated action of osteoclasts (cells that …
Morphological characters can strongly influence early animal relationships inferred from phylogenomic data sets
There are considerable phylogenetic incongruencies between morphological and
phylogenomic data for the deep evolution of animals. This has contributed to a heated …
phylogenomic data for the deep evolution of animals. This has contributed to a heated …
Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes
Genome-wide association studies have successfully discovered thousands of common
variants associated with human diseases and traits, but the landscape of rare variation in …
variants associated with human diseases and traits, but the landscape of rare variation in …
The genetic architecture and population genomic signatures of glyphosate resistance in Amaranthus tuberculatus
Much of what we know about the genetic basis of herbicide resistance has come from
detailed investigations of monogenic adaptation at known target‐sites, despite the …
detailed investigations of monogenic adaptation at known target‐sites, despite the …