HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …

Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line
treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation …

Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious
diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C …

Abstract Treatment with highly active antiretroviral therapy (HAART) can prolong a patient's
life-span by disrupting pivotal steps in the replication cycle of the human immunodeficiency …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic
of coronavirus disease in 2019 (COVID-19). Genome surveillance is a key method to track …

Drug discovery of human immunodeficiency virus (HIV) is a hot field in medicinal chemistry
community for many years. The diarylpyrimidines (DAPYs) are the second‐generation non …

Covalent inhibitors of wild-type HIV-1 reverse transcriptase (CRTIs) are reported. Three
compounds derived from catechol diether non-nucleoside inhibitors (NNRTIs) with addition …

Inspired by our previous efforts to improve the drug-resistance profiles of HIV-1 non-
nucleoside reverse transcriptase inhibitors (NNRTIs), a novel series of “dual-site” binding …

Despite the low prevalence of HIV-1 in Israel, continuous waves of immigration may have
impacted the local epidemic. We characterized all people diagnosed with HIV-1 in Israel in …

Abstract Background The newer generation NNRTIs, including doravirine and rilpivirine,
were designed to show high potency and overcome K103N, Y181C and G190A resistance …