In less than two decades, three deadly zoonotic coronaviruses, severe acute respiratory
syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS …

The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …

Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a
necessity to develop direct-acting antivirals that can be readily administered and are active …

The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …

The coronavirus SARS-CoV-2 main protease, Mpro, is conserved among coronaviruses with
no human homolog and has therefore attracted significant attention as an enzyme drug …

Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS …

Viral proteases are critical enzymes for the maturation of many human pathogenic viruses
and thus are key targets for direct acting antivirals (DAAs). The current viral pandemic …

The global pandemic that shut down the world in 2020 was caused by the virus, SARS CoV-
2. The chemistry of the various nonstructural proteins (NSP3, NSP5, NSP12, NSP13 …

The COVID-19 pandemic has resulted in 198 million reported infections and more than 4
million deaths as of July 2021 (covid19. who. int). Research to identify effective therapies for …

COVID-19, the disease caused by the newly discovered coronavirus—SARS-CoV-2, has
created a global health, social, and economic crisis. As of mid-January 2021, there are over …