Epidemiology and determinants of obesity in China
Obesity has become a major public health issue in China. Overweight and obesity have
increased rapidly in the past four decades, and the latest national prevalence estimates for …
increased rapidly in the past four decades, and the latest national prevalence estimates for …
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …
to the rapidly increased prevalence of overweight and obesity. To this point …
[HTML][HTML] The carbohydrate-insulin model: a physiological perspective on the obesity pandemic
According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …
Body adiposity is highly heritable, and human genetic studies can lead to biological and …
Direct medical costs of obesity in the United States and the most populous states
BACKGROUND: After a dramatic increase in prevalence over several decades, obesity has
become a major public health crisis in the United States. Research to date has consistently …
become a major public health crisis in the United States. Research to date has consistently …
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic
health. To date, most genetic studies of glycemic traits have focused on individuals of …
health. To date, most genetic studies of glycemic traits have focused on individuals of …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
[PDF][PDF] Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …
expected to rise further, secondary to the growing aging, sedentary population. The strain on …
Elevated C-reactive protein in patients with depression, independent of genetic, health, and psychosocial factors: results from the UK Biobank
MC Pitharouli, SP Hagenaars… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: The authors investigated the pathways (genetic, environmental, lifestyle, medical)
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …
leading to inflammation in major depressive disorder using C-reactive protein (CRP) …
[HTML][HTML] Mendelian randomisation for mediation analysis: current methods and challenges for implementation
Mediation analysis seeks to explain the pathway (s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …