Air pollution and the airways: lessons from a century of human urbanization

J Goossens, AC Jonckheere, LJ Dupont, DMA Bullens - Atmosphere, 2021 - mdpi.com
Since the industrial revolution, air pollution has become a major problem causing several
health problems involving the airways as well as the cardiovascular, reproductive, or …

Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology

K Lu, KP Lai, T Stoeger, S Ji, Z Lin, X Lin… - Journal of hazardous …, 2021 - Elsevier
Concerns that airborne microplastics (MP) may be detrimental to human health are rising.
However, research on the effects of MP on the respiratory system are limited. We tested the …

AHR/ROS-mediated mitochondria apoptosis contributes to benzo [a] pyrene-induced heart defects and the protective effects of resveratrol

Y Huang, J Zhang, Y Tao, C Ji, S Aniagu, Y Jiang… - Toxicology, 2021 - Elsevier
Abstract Benzo [a] pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon, is widely
present in the environment. BaP-induced heart defects have been frequently reported, but …

CaMKII oxidation regulates cockroach allergen–induced mitophagy in asthma

Y Zhang, DC Do, X Hu, J Wang, Y Zhao… - Journal of Allergy and …, 2021 - Elsevier
Background Autophagy plays an important role in causing inflammatory responses initiated
by environmental pollutants and respiratory tract infection. Objective We sought to …

Epithelial aryl hydrocarbon receptor protects from mucus production by inhibiting ROS-triggered NLRP3 inflammasome in asthma

X Hu, Y Shen, Y Zhao, J Wang, X Zhang, W Tu… - Frontiers in …, 2021 - frontiersin.org
Background Despite long-standing recognition in the significance of mucus overproduction
in asthma, its etiology remains poorly understood. Muc5ac is a secretory mucin that has …

Benzo (a) pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFβ1 Signaling Activation Through the Aryl Hydrocarbon Receptor–RhoA Axis in Asthma

E Wang, W Tu, DC Do, X Xiao, SB Bhatti… - Frontiers in …, 2021 - frontiersin.org
We have previously demonstrated that benzo (a) pyrene (BaP) co-exposure with
dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1-induced airway …

The aggravation of allergic airway inflammation with dibutyl phthalate involved in Nrf2-mediated activation of the mast cells

X Wang, Z Lv, B Han, S Li, Q Yang, P Wu, J Li… - Science of The Total …, 2021 - Elsevier
Dibutyl phthalate (DBP)-an organic pollutant-is ubiquitous in the environment. DBP as an
immune adjuvant is related to the development of multiple allergic diseases. However, the …

[HTML][HTML] miR-122–5p regulates hepatocytes damage caused by BaP and DBP co-exposure through SOCS1/STAT3 signaling in vitro

Y Liu, W Chen, J Chen, Y Ma, Y Cen, S Wang… - Ecotoxicology and …, 2021 - Elsevier
Highlights•BaP or/and DBP caused excessive apoptosis and disorder of inflammatory
cytokines secretion in hepatocytes.•Co-exposure to BaP and DBP exacerbated hepatocyte …

Lycopene inhibits toll-like receptor 4-mediated expression of inflammatory cytokines in house dust mite-stimulated respiratory epithelial cells

J Choi, JW Lim, H Kim - Molecules, 2021 - mdpi.com
House dust mites (HDM) are critical factors in airway inflammation. They activate respiratory
epithelial cells to produce reactive oxygen species (ROS) and activate Toll-like receptor 4 …

Proximity to heavy traffic roads and patient characteristics of late of onset asthma in an urban asthma center

TY Lin, HC Lin, YS Liu, YL Lo, CH Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Traffic-related pollution is associated with the onset of asthma and the
development of different phenotypes of asthma. Few studies have investigated the …