JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

Monocytes and macrophages in COVID-19: Friends and foes

S Meidaninikjeh, N Sabouni, HZ Marzouni, S Bengar… - Life sciences, 2021 - Elsevier
The COVID-19 is a novel infectious disease caused by SARS-CoV-2 and is known as a
pandemic emergency that has led to a high rate of mortality throughout the world. Evidence …

[HTML][HTML] Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 …

H Zhu, Z Jian, Y Zhong, Y Ye, Y Zhang, X Hu… - Frontiers in …, 2021 - frontiersin.org
Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

[HTML][HTML] The use of medicinal plants to prevent COVID-19 in Nepal

D Khadka, MK Dhamala, F Li, PC Aryal… - Journal of ethnobiology …, 2021 - Springer
Background Medicinal plants are the fundamental unit of traditional medicine system in
Nepal. Nepalese people are rich in traditional medicine especially in folk medicine …

The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

GA De Erausquin, H Snyder, M Carrillo… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction The increasing evidence of SARS‐CoV‐2 impact on the central nervous system
(CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's …

[HTML][HTML] A mechanistic link between selenium and coronavirus disease 2019 (COVID-19)

S Khatiwada, A Subedi - Current Nutrition Reports, 2021 - Springer
Abstract Purpose of Review Coronavirus disease 2019 (COVID-19) is a rapidly emerging
disease caused by a highly contagious virus called severe acute respiratory syndrome …

[HTML][HTML] Probiotics-based foods and beverages as future foods and their overall safety and regulatory claims

S Koirala, AK Anal - Future Foods, 2021 - Elsevier
The increasing research on science and innovation has shifted consumer awareness from
conventional to functional foods that are more nutritious and healthier. The ideation of …

Cholesterol, lipoproteins, and COVID-19: Basic concepts and clinical applications

E Kočar, T Režen, D Rozman - … et Biophysica Acta (BBA)-Molecular and …, 2021 - Elsevier
Cholesterol is being recognized as a molecule involved in regulating the entry of the SARS-
CoV-2 virus into the host cell. However, the data about the possible role of cholesterol …

[HTML][HTML] Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation

B Bonnet, J Cosme, C Dupuis, E Coupez, M Adda… - …, 2021 - thelancet.com
Background SARS-CoV-2 has been responsible for considerable mortality worldwide, owing
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …