A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder
AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram… - Cellular signalling, 2021 - Elsevier
The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …
and a half, more than 200 million people have been infected and more than four million …
Trametinib enhances ATRA-induced differentiation in AML cells
H Lu, Z Li, M Ding, C Liang, X Weng… - Leukemia & …, 2021 - Taylor & Francis
All-trans retinoic acid (ATRA) is only clinically useful in acute promyelocytic leukemia (APL),
but not other subtypes of acute myeloid leukemia (AML). In the present study, a clinically …
but not other subtypes of acute myeloid leukemia (AML). In the present study, a clinically …
[HTML][HTML] Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells
N Kazim, A Yen - Oncotarget, 2021 - ncbi.nlm.nih.gov
Retinoic acid (RA) is a fundamental regulator of cell cycle and cell differentiation. Using a
leukemic patient-derived in vitro model of a non-APL AML, we previously found that RA …
leukemic patient-derived in vitro model of a non-APL AML, we previously found that RA …
Evidence of off-target effects of bosutinib that promote retinoic acid-induced differentiation of non-APL AML cells
N Kazim, A Yen - Cell Cycle, 2021 - Taylor & Francis
In the present study, we determined the effects of the Src family kinase (SFK) inhibitor,
Bosutinib, and the engineered loss of the Lyn SFK on all-trans retinoic acid-induced …
Bosutinib, and the engineered loss of the Lyn SFK on all-trans retinoic acid-induced …
Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines
EJ Norris, YC Patel, KE Klotz, N Steuerwald… - Leukemia & …, 2021 - Taylor & Francis
All trans retinoic acid (ATRA) has demonstrated curative activity in acute promyelocytic
leukemia (APL), a distinct subtype of acute myeloid leukemia (AML), that is characterized by …
leukemia (APL), a distinct subtype of acute myeloid leukemia (AML), that is characterized by …
Salt-inducible kinase inhibition sensitizes human acute myeloid leukemia cells to all-trans retinoic acid-induced differentiation
XW Zhang, X Shen, WY Long, H Xiao, FJ Li… - International Journal of …, 2021 - Springer
Differentiation therapies with all-trans retinoic acid (ATRA) have been successful in treating
acute promyelocytic leukemia, a rare subtype of acute myeloid leukemia (AML). However …
acute promyelocytic leukemia, a rare subtype of acute myeloid leukemia (AML). However …