Scientific rationale for developing potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

RR Goel, MM Painter, SA Apostolidis, D Mathew… - Science, 2021 - science.org
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

S Feng, DJ Phillips, T White, H Sayal, PK Aley, S Bibi… - Nature medicine, 2021 - nature.com
The global supply of COVID-19 vaccines remains limited. An understanding of the immune
response that is predictive of protection could facilitate rapid licensure of new vaccines. Data …

Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

J Mateus, JM Dan, Z Zhang, C Rydyznski Moderbacher… - Science, 2021 - science.org
INTRODUCTION Understanding human immune responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) RNA vaccines is of interest for a panoply of reasons …

Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors

RT Shroff, P Chalasani, R Wei, D Pennington… - Nature medicine, 2021 - nature.com
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
shown high efficacy, but immunocompromised participants were excluded from controlled …

Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection

A Israel, Y Shenhar, I Green, E Merzon, A Golan-Cohen… - Vaccines, 2021 - mdpi.com
Immune protection following either vaccination or infection with SARS-CoV-2 is thought to
decrease over time. We designed a retrospective study, conducted at Leumit Health …

Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies

LM Greenberger, LA Saltzman, JW Senefeld… - Cancer cell, 2021 - cell.com
It has been reported that 15%–25% of patients with hematologic malignancies fail to make
anti-spike (anti-S) antibodies in response to full dosing of SARS-CoV-2 mRNA vaccines …

[HTML][HTML] Booster of mRNA-1273 strengthens SARS-CoV-2 Omicron neutralization

NA Doria-Rose, X Shen, SD Schmidt, S O'Dell… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased
transmissibility and potential for reduced susceptibility to antibody neutralization. To assess …

Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia

NJ Dashdorj, OF Wirz, K Röltgen, E Haraguchi… - Cell host & …, 2021 - cell.com
Different SARS-CoV-2 vaccines are approved in various countries, but few direct
comparisons of the antibody responses they stimulate have been reported. We collected …

[HTML][HTML] Heterologous SARS-CoV-2 booster vaccinations–preliminary report

RL Atmar, KE Lyke, ME Deming, LA Jackson… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective,
breakthrough infections are occurring. Booster vaccinations have recently received …