Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Wound healing: from passive to smart dressings

M Farahani, A Shafiee - Advanced Healthcare Materials, 2021 - Wiley Online Library
The universal increase in the number of patients with nonhealing skin wounds imposes a
huge social and economic burden on the patients and healthcare systems. Although, the …

[HTML][HTML] The limitless future of RNA therapeutics

TR Damase, R Sukhovershin, C Boada… - … in bioengineering and …, 2021 - frontiersin.org
Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

The growth of siRNA-based therapeutics: Updated clinical studies

MM Zhang, R Bahal, TP Rasmussen… - Biochemical …, 2021 - Elsevier
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

siRNA: Mechanism of action, challenges, and therapeutic approaches

W Alshaer, H Zureigat, A Al Karaki, A Al-Kadash… - European journal of …, 2021 - Elsevier
Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …

[HTML][HTML] Transfection types, methods and strategies: a technical review

ZX Chong, SK Yeap, WY Ho - PeerJ, 2021 - peerj.com
Transfection is a modern and powerful method used to insert foreign nucleic acids into
eukaryotic cells. The ability to modify host cells' genetic content enables the broad …

[HTML][HTML] Recent advances in oligonucleotide therapeutics in oncology

H Xiong, RN Veedu, SD Diermeier - International Journal of Molecular …, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

miRNAs; a novel strategy for the treatment of COVID‐19

H Ying, M Ebrahimi, M Keivan… - Cell biology …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is the seventh member of the bat severe
acute respiratory syndrome family. COVID‐19 can fuse their envelopes with the host cell …

The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy

S Liu, AR Khan, X Yang, B Dong, J Ji, G Zhai - Journal of Controlled …, 2021 - Elsevier
Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …

[HTML][HTML] The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: pathways, mechanisms and translational opportunities

E Lauretti, K Dabrowski, D Praticò - Ageing Research Reviews, 2021 - Elsevier
In the past two decades, advances in sequencing technology and analysis of the human and
mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) …